La Sipnei sulla rivista della New York Academy of Sciences

pubb. domenica, 20 Maggio, 2018

Negli Annals of New York Academy of Sciences è stata pubblicata, in anteprima, la review scritta dai soci SIPNEI Anna Giulia Bottaccioli, Francesco Bottaccioli e Andrea Minelli. Un importante traguardo e motivo di soddisfazione per gli autori e per la SIPNEI tutta.

Ann N Y Acad Sci. 2018 May 15. doi: 10.1111/nyas.13728. [Epub ahead of print]

Stress and the psyche-brain-immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review.

Bottaccioli AG1Bottaccioli F2Minelli A3.

Author information

    1. 1. Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Università degli Studi di Roma La Sapienza, Internal Medicine Unit,
    1. 2. Dipartimento di Medicina Clinica, Università degli Studi dell’Aquila, Sanita Pubblica Scienze della Vita e dell’Ambiente, L’Aquila, Italy.
    1. 3. Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Urbino, Italy.


In the last decades, psychoneuroendocrineimmunology research has made relevant contributions to the fields of neuroscience, psychobiology, epigenetics, molecular biology, and clinical research by studying the effect of stress on human health and highlighting the close interrelations between psyche, brain, and bodily systems. It is now well recognized that chronic stress can alter the physiological cross-talk between brain and biological systems, leading to long-lasting maladaptive effects (allostatic overload) on the nervous, immune, endocrine, and metabolic systems, which compromises stress resiliency and health. Stressful conditions in early life have been associated with profound alterations in cortical and subcortical brain regions involved in emotion regulation and the salience network, showing relevant overlap with different psychiatric conditions. This paper provides a summary of the available literature concerning the notable effects of stress on the brain and immune system. We highlight the role of epigenetics as a mechanistic pathway mediating the influences of the social and physical environment on brain structure and connectivity, the immune system, and psycho-physical health in psychiatric diseases. We also summarize the evidence regarding the effects of stress management techniques (mainly psychotherapy and meditation practice) on clinical outcomes, brain neurocircuitry, and immune-inflammatory network in major psychiatric diseases.



NF-κB; allostasis; epigenetics; mind-body therapies; psychoneuroendocrineimmunology; stress



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